Ferrada, Evandro and Wagner, Andreas 2008

Ferrada, Evandro and Wagner, Andreas. 2008. Protein robustness promotes evolutionary innovations on large evolutionary time-scales. Proceedings of the Royal Society of London B: Biological Sciences 275. 1595-1602. The Royal Society.

@article{555162,
  author    = {Ferrada, Evandro and Wagner, Andreas},
  journal   = {Proceedings of the Royal Society of London B: Biological Sciences},
  number    = {1643},
  pages     = {1595-1602},
  publisher = {The Royal Society},
  title     = {Protein robustness promotes evolutionary innovations on large evolutionary time-scales},
  url       = {http://rspb.royalsocietypublishing.org/content/275/1643/1595.full.pdf},
  volume    = {275},
  year      = {2008},
  abstract  = {Recent laboratory experiments suggest that a molecules ability to evolve neutrally is important for its ability to generate evolutionary innovations. In contrast to laboratory experiments, life unfolds on time-scales of billions of years. Here, we ask whether a molecules ability to evolve neutrally—a measure of its robustness—facilitates evolutionary innovation also on these large time-scales. To this end, we use protein designability, the number of sequences that can adopt a given protein structure, as an estimate of the structures ability to evolve neutrally. Based on two complementary measures of functional diversity—catalytic diversity and molecular functional diversity in gene ontology—we show that more robust proteins have a greater capacity to produce functional innovations. Significant associations among structural designability, folding rate and intrinsic disorder also exist, underlining the complex relationship of the structural factors that affect protein evolution.},
  doi       = {https://doi.org/10.1098/rspb.2007.1617},
  lgcode    = {Aukan [djk] (computerized assignment from "scales")},
  src       = {evobib}
}